NEW YORK (AP) — U.S. stocks tumbled in early trading Wednesday as central banks around the world cut interest rates and increased fears that global growth is being crimped by the U.S.-China trade war.

Every major U.S. index fell in the early going, putting stocks back on a course for losses after briefly breaking a six-day losing streak on Tuesday. Investors were back in defensive mode headed for relatively safe holdings.

Bond prices spiked again, sending the yield on the 10-year Treasury down to 1.62% from 1.74% late Tuesday, a very large move. Yields are at their lowest level in nearly three years. That benchmark yield has retreated from its recent high of 3.23% last November as expectations of economic growth have steadily faded.

“The Treasury market is trading much higher this morning as investors continue to seek a safer haven, completely unsure as to what may happen next,” Kevin Giddis, head of fixed income capital markets at Raymond James wrote in a report.

Banks sustained some of the worst losses as bond yields fell sharply. Lower bond yields mean lower interest rates on mortgages and other kinds of loans, which mean lower profits for banks. JPMorgan Chase fell 3.2% and Bank of America fell 3.6%.

The dimming expectations for global growth also send the price of crude oil sharply lower. Benchmark U.S. crude was down 3% at $52 a barrel. That helped pull energy sector stocks lower. Occidental Petroleum gave up 3.1%.

Big technology stocks, longtime investor favorites, also posted hefty losses. IBM lost 2%.

The S&P 500 index fell 1.1% as of 10:16 a.m. Eastern time. The Dow Jones Industrial Average fell 352 points, or 1.4%, to 25,509. It was down as much as 589 earlier.

The Nasdaq fell 0.6%

China on Monday allowed its currency, the yuan, to weaken against the U.S. dollar in response to U.S. threats to add more tariffs to Chinese goods. China stabilized the yuan on Tuesday and that helped lift U.S. stocks a day after they endured their worst day of the year. The volatile trading has already put a dent in the major indexes yearly gains. The S&P 500 is down 4.3% for August.

Central banks in New Zealand, India and Thailand cut key interest rates Wednesday and investors around the world fear that the escalating trade war between the U.S. and China will severely damage global growth.

After the surprise interest-rate cuts, bond yields sank around the world as investors scrambled for safety. They also poured into gold, which jumped to its highest price in more than six years.

“There is almost a paranoia amongst central bankers to avoid any potential financial hiccups that might hurt the real economy and cause a slowdown,” Jefferies strategist Sean Darby wrote in a report.

A key gauge of fear in the marketplace surged 13.7%. The VIX index, which measures how much traders are paying to protect themselves from swings in the S&P 500, was still below where it was at the start of the year, when recession fears were surging, but it’s close to its highest level of the year.

European and Asian indexes were mixed.

Disney fell 5.8% after disappointing investors with a sharp third quarter profit plunge that fell far short of Wall Street forecasts. The entertainment company said underperformance from its Fox movie and TV studio helped weigh down the fiscal third quarter financial results. It bought Fox’s entertainment business in March for $71 billion.

Match Group shares jumped 19.5% after the operator of Tinder, OKCupid and other dating sights beat Wall Street’s second quarter earnings forecasts. The company reported a surge in Tinder subscribers and raised its revenue forecast for the year.

Drugstore operator CVS Health rose 5.8 % after swinging to a second quarter profit and handily beating Wall Street forecasts. The company attributed part of the gains to health insurer Aetna, which it bought for $69 billion in November.